Dibutyryl cAMP (DbcAMP) Induces Serum and Glucocorticoid‐Induced Kinase1 (sgk1) Expression and Initiates Amiloride‐Sensitive Na+ Transport in Rat Submandibular Gland Epithelial (SMG‐C6) Cells
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چکیده
منابع مشابه
cAMP-stimulated Na+ transport in H441 distal lung epithelial cells: role of PKA, phosphatidylinositol 3-kinase, and sgk1.
H441 cells, a bronchiolar epithelial cell line, develop a cAMP-regulated benzamil-sensitive Na+ transport pathway on permeable supports (Itani OA, Auerbach SD, Husted RF, Volk KA, Ageloff S, Knepper MA, Stokes JB, Thomas CP. Am J Physiol Lung Cell Mol Physiol 282: L631-L641, 2002). To understand the molecular basis for the stimulation of Na+ transport, we delineated the role of specific intrace...
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In this study, the effect of various doses of ouabain (1, 2, and 5 mg/kg, i.p.) on weight and flow rate of submandibular gland (SMG) and changes in zinc and copper levels in pure saliva and serum of rats was investigated. The time interval between injection of drug and sampling was 30 min. In addition, the effect of a single and toxic dose of ouabain (5 mg/kg, i.p.) in various time intervals (3...
متن کاملAlveolar Epithelial Ion and Fluid Transport Glucocorticoid-stimulated lung epithelial Na transport is associated with regulated ENaC and sgk1 expression
OMAR A. ITANI,1 SCOTT D. AUERBACH,1 RUSSELL F. HUSTED,1 KENNETH A. VOLK,1 SHANA AGELOFF,2 MARK A. KNEPPER,2 JOHN B. STOKES,1,3 AND CHRISTIE P. THOMAS1,3 1Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242; 3Veterans Affairs Medical Center, Iowa City, Iowa 52246; and 2Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute,...
متن کاملHypotonic induction of SGK1 and Na+ transport in A6 cells.
Serum and glucocorticoid-regulated kinase-1 (SGK1) is a serine-threonine kinase that is regulated at the transcriptional level by numerous regulatory inputs, including mineralocorticoids, glucocorticoids, follicle-stimulating hormone, and osmotic stress. In the distal nephron, SGK1 is induced by aldosterone and regulates epithelial Na+ channel-mediated transepithelial Na+ transport. In other ti...
متن کاملGlucocorticoid-stimulated lung epithelial Na(+) transport is associated with regulated ENaC and sgk1 expression.
H441 cells, a bronchiolar epithelial cell line, develop a glucocorticoid-regulated amiloride-sensitive Na(+) transport pathway on permeable supports (R. Sayegh, S. D. Auerbach, X. Li, R. Loftus, R. Husted, J. B. Stokes, and C. P. Thomas. J Biol Chem 274: 12431-12437, 1999). To understand its molecular basis, we examined the effect of glucocorticoids (GC) on epithelial Na(+) channel (ENaC)-alpha...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a795-b